本研究では、助成金NIHM R01 MH091816とTDGのR21 MH084043によってサポートされています。

<ol>
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著者は、利害の衝突を宣言しません。

FST（と呼ばれることもありますPorsoltの水泳試験）は、ラットで最初に開発し、Porsoltと同僚12,13によってマウスのために変更されました。我々の研究室で成功し、上記のプロトコルに加えて、主に微妙なテストの修正の数は、（完全な見直し1 HascoëtとBourinを参照してください）発表されています。それは抗うつ薬と基礎および臨床研究3,14-16で様々な行動と神経生物学...

<ul><li>水タンク</li><li>温度計</li><li>タイマー</li><li>ビデオカメラ</li><li>ホワイトノイズ発生器（オプション） </li><li>乾燥紙</li></ul>

the mouse forced swim test

強制水泳試験は抗うつ薬、新規化合物の抗うつ効果、および状態のようなうつ病をレンダリングまたは予防を目的としている実験操作の評価に使用されるげっ歯類の行動試験です。マウスは、水で満たされており、彼らの脱出に関連するモビリティの挙動が測定され避けられない透明なタンクに配置されます。強制水泳試験では、確実に実施するのは簡単であり、それは最小限の特殊な装置を必要とします。強制水泳試験の実装を成功させるには、一定の手続きの詳細およびマウスへの不当なストレスの最小化に従う必要があります。プロトコルの説明および添付のビデオでは、我々はどのようにそれらを避けるために、結果の解釈とに有害かもしれない潜在的な落とし穴に重点を置いてこの試験のマウスのバージョンを実施する方法について説明します。さらに、我々はテストで明らかに動作が評価される方法について説明します。

Watch this Scientific Journal Video about The Mouse Forced Swim Test at JoVE.com

The Mouse Forced Swim Test

強制水泳試験は、げっ歯類の潜在的な抗うつ効果を評価するための実験的なアプローチとして検証されます。実験動物は、水のタンクに配置され、エスケープ関連のモビリティの挙動が定量化される。この試験のマウスのバージョンに共通の手順が説明されています。

マウス強制水泳試験

The forced swim test is a rodent behavioral test used for evaluation of antidepressant drugs, antidepressant efficacy of new compounds, and experimental ...

Research

JoVE Journal

Neuroscience

103.8K ビュー.  University of Maryland School of Medicine. 強制水泳試験は、げっ歯類の潜在的な抗うつ効果を評価するための実験的なアプローチとして検証されます。実験動物は、水のタンクに配置され、エスケープ関連のモビリティの挙動が定量化される。この試験のマウスのバージョンに共通の手順が説明されています。