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JoVE Journal

Immunology and Infection

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Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)

17.7K Views

07:13 min

March 25th, 2016

March 25th, 2016

17,738 Views

0:05

Title

0:57

Timed-mating Pair Setup

2:23

Poly(I:C) Injection

3:55

MIA Adult Offsrping Behavioral Abnormality Evaluation

5:33

Results: MIA Adult Offsrping Exhibit Abnormalities Associated with Autism and Schizophrenia

6:42

Conclusion

필기록

The overall goal of this procedure is to induce maternal immune activation, or MIA, in mice by intraperitoneal injection of the viral mimic poly at the mid-gestational embryonic stage. This method can help us answer key questions in a neuro-immuno

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Maternal immune activation (MIA) is a model for an environmental risk factor of autism and schizophrenia. The goal of this article is to provide a step-by-step procedure of how to induce MIA in the pregnant mice in order to enhance the reproducibility of this model.

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