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Induction of Myocardial Infarction in Adult Zebrafish Using Cryoinjury

DOI :

10.3791/3666-v

11:12 min

April 18th, 2012

April 18th, 2012

21,242 Views

1Department of Biology, Unit of Zoology, University of Fribourg, Fribourg, Switzerland

Zebrafish represents a valuable model to study the mechanisms of heart regeneration in vertebrates. Here, we present a protocol for induction of a heart infarct in adult zebrafish using cryoinjury. This method results in massive cell death within 20% of the ventricular wall, similar to that observed in mammalian infarcts.

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Myocardial Infarction

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