Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production

11.1K Views

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10:20 min

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October 26th, 2018

DOI :

10.3791/58428-v

October 26th, 2018

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Eric Schopf*¹, Christopher M. Waldmann*²^,³, Jeffrey Collins²^,⁴, Christopher Drake¹, Roger Slavik²^,³, R. Michael van Dam²^,⁴

¹SOFIE, ²Department of Molecular & Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), ³Ahmanson Translational Imaging Division, University of California, Los Angeles (UCLA), ⁴Crump Institute for Molecular Imaging, University of California, Los Angeles (UCLA)

Summary

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Keywords Automated Synthesis

Fluorination Reaction

Disposable Cassettes

Reaction Vessels

Reagent Vials

Chapters in this video

0:04

Title

0:53

Synthesis Protocol Automation

2:13

Setup for Automated Synthesis

5:25

Automated Synthesis, Purification and Formulation, and Post-Run System Shutdown

9:10

Results: Representative Quality Control Test Data Summary for Three Validation Batches

9:33

Conclusion

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