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Measuring RAN Peptide Toxicity in C. elegans

DOI :

10.3791/61024-v

April 30th, 2020

April 30th, 2020

6,423 Views

1Graduate Program in Cell Biology and Molecular Physiology, University of Pittsburgh, 2Department of Pediatrics, University of Pittsburgh School of Medicine

Repeat-associated non-ATG-dependent translational products are emerging pathogenic features of several repeat expansion-based diseases. The goal of the protocol described is to evaluate toxicity caused by these peptides using behavioral and cellular assays in the model system C. elegans.

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Keywords RAN Peptides

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