This study was supported in part by the grants from the Ministry of Science and Technology, Taiwan (MOST 103-2511-S-002-007). The authors would like to thank Dr. Chih-Hsien Wu and Mr. Jen-Chih Sung for helping the preparation of the photographs and film.

This procedure was approved by the Institutional Review Board of the National Taiwan University Hospital and registered at ClinicalTrials.gov (NCT02952768).
1. Instrumentation
<ol>
	<li>Use a US machine equipped with a curvilinear 2&#8211;5 MHz probe. A portable US is more suitable for CPR.</li>
</ol>
2. Personnel and their roles in the resuscitation team
<ol>
	<li>Ideally, a resuscitation team should be comprised of six members: 1) a leader; 2) a member for airway ...

<ol>
	<li>Soar, J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=European+Resuscitation+Council+Guidelines+for+Resuscitation+2015:+Section+3.+Adult+advanced+life+support.">European Resuscitation Council Guidelines for Resuscitation 2015: Section 3. Adult advanced life support.</a> Resuscitation. 95, 100-147 (2015).</li><li>Takeda, T., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+assessment+of+three+methods+to+verify+tracheal+tube+placement+in+the+emergency+setting.">The assessment of three methods to verify tracheal tube placement in the emergency setting.</a> Resuscitation. 56 (2), 153-157 (2003).</li><li>Levine, R., Wayne, M., Miller, C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=End-tidal+carbon+dioxide+and+outcome+of+out-of-hospital+cardiac+arrest.">End-tidal carbon dioxide and outcome of out-of-hospital cardiac arrest.</a> New England Journal of Medicine. 337, 301-306 (1997).</li><li>Moule, P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Checking+the+carotid+pulse:+diagnostic+accuracy+in+students+of+the+healthcare+professions.">Checking the carotid pulse: diagnostic accuracy in students of the healthcare professions.</a> Resuscitation. 44 (3), 195-201 (2000).</li><li>Sitzwohl, C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Endobronchial+intubation+detected+by+insertion+depth+of+endotracheal+tube,+bilateral+auscultation,+or+observation+of+chest+movements:+randomised+trial.">Endobronchial intubation detected by insertion depth of endotracheal tube, bilateral auscultation, or observation of chest movements: randomised trial.</a> British Medical Journal. 341, 5943 (2010).</li><li>Monsieurs, K., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=European+Resuscitation+Council+Guidelines+for+Resuscitation+2015:+Section+1.+Executive+summary.">European Resuscitation Council Guidelines for Resuscitation 2015: Section 1. Executive summary.</a> Resuscitation. 95, 1-80 (2015).</li><li>Breitkreutz, R., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Focused+echocardiographic+evaluation+in+life+support+and+peri-resuscitation+of+emergency+patients:+a+prospective+trial.">Focused echocardiographic evaluation in life support and peri-resuscitation of emergency patients: a prospective trial.</a> Resuscitation. 81 (11), 1527-1533 (2010).</li><li>Hernandez, C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=C.A.U.S.E.:+Cardiac+arrest+ultra-sound+exam--a+better+approach+to+managing+patients+in+primary+non-arrhythmogenic+cardiac+arrest.">C.A.U.S.E.: Cardiac arrest ultra-sound exam--a better approach to managing patients in primary non-arrhythmogenic cardiac arrest.</a> Resuscitation. 76 (2), 198-206 (2008).</li><li>Perera, P., Mailhot, T., Riley, D., Mandavia, D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+RUSH+exam:+Rapid+Ultrasound+in+SHock+in+the+evaluation+of+the+critically+lll.">The RUSH exam: Rapid Ultrasound in SHock in the evaluation of the critically lll.</a> Emergency Medicine Clinics of North America. 28 (1), 29-56 (2010).</li><li>Blyth, L., Atkinson, P., Gadd, K., Lang, E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Bedside+focused+echocardiography+as+predictor+of+survival+in+cardiac+arrest+patients:+a+systematic+review.">Bedside focused echocardiography as predictor of survival in cardiac arrest patients: a systematic review.</a> Academic Emergency Medicine. 19, 1119-1126 (2012).</li><li>Lien, W. C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=US-CAB+protocol+for+ultrasonographic+evaluation+during+cardiopulmonary+resuscitation:+validation+and+potential+impact.">US-CAB protocol for ultrasonographic evaluation during cardiopulmonary resuscitation: validation and potential impact.</a> Resuscitation. 127, 125-131 (2018).</li><li>Chou, H. C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Real-time+tracheal+ultrasonography+for+confirmation+of+endotracheal+tube+placement+during+cardiopulmonary+resuscitation.">Real-time tracheal ultrasonography for confirmation of endotracheal tube placement during cardiopulmonary resuscitation.</a> Resuscitation. 84 (12), 1708-1712 (2013).</li><li>Sim, S. S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Ultrasonographic+lung+sliding+sign+in+confirming+proper+endotracheal+intubation+during+emergency+intubation.">Ultrasonographic lung sliding sign in confirming proper endotracheal intubation during emergency intubation.</a> Resuscitation. 83 (3), 307-312 (2012).</li><li>Lien, W. C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+novel+US-CAB+protocol+for+ultrasonographic+evaluation+during+cardiopulmonary+resuscitation.">A novel US-CAB protocol for ultrasonographic evaluation during cardiopulmonary resuscitation.</a> Resuscitation. 115, 1-2 (2017).</li><li>Roelandt, J. R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Ultrasound+stethoscopy.">Ultrasound stethoscopy.</a> European Journal of Internal Medicine. 15, 337-347 (2004).</li><li>Lien, W. C., Chang, W. T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+Potential+Pitfall+of+Tracheal+Ultrasound+for+the+Confirmation+of+Endotracheal+Intubations.">A Potential Pitfall of Tracheal Ultrasound for the Confirmation of Endotracheal Intubations.</a> Journal of Ultrasound in Medicine. , (2019).</li><li>Huis In't Veld, M. A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Ultrasound+use+during+cardiopulmonary+resuscitation+is+associated+with+delays+in+chest+compressions.">Ultrasound use during cardiopulmonary resuscitation is associated with delays in chest compressions.</a> Resuscitation. 119, 95-98 (2017).</li><li>Clattenburg, E. J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Point-of-care+ultrasound+use+in+patients+with+cardiac+arrest+is+associated+prolonged+cardiopulmonary+resuscitation+pauses:+A+prospective+cohort+study.">Point-of-care ultrasound use in patients with cardiac arrest is associated prolonged cardiopulmonary resuscitation pauses: A prospective cohort study.</a> Resuscitation. 122 (1), 65-68 (2018).</li><li>Lien, W. C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Data+on+evaluation+of+proficiency+for+the+US-CAB+curriculum.">Data on evaluation of proficiency for the US-CAB curriculum.</a> Data in Brief. 16 (17), 965-968 (2017).</li><li>Lien, W. C., Chang, W. T., Ma, M. H., Chen, W. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Ultrasonography+during+CPR:+Hands-off+or+hands-on.">Ultrasonography during CPR: Hands-off or hands-on.</a> Resuscitation. 125, 8-10 (2018).</li></ol>

US is a noninvasive, real-time, and readily available imaging modality in emergency and critical care settings. Application of US during CPR plays an important role in diagnosis, guidance of therapeutic intervention, or monitoring15. While many US protocols have been introduced for use with CPR, the US-CAB protocol complies with the sequence of advanced life support (ALS). It integrates important US techniques to detect possibly reversible causes of any issues, and to evaluate the C-A-B status dur...

Effective cardiopulmonary resuscitation (CPR) for cardiac arrest is key to successful revival of a patient. Circulation (C), airway (A), and breathing (B) are the three crucial components in either basic (BLS) or advanced life support (ALS). The evaluation of the C-A-B status during CPR basically relies on pulse checks, auscultation, and capnography1. In true clinical conditions, however, CPR is often complex and chaotic, and these methods may have limitations2,3. For example, the accuracy of pulse checks is often suboptimal even when performed by healthcare providers4. More than half of one lung intubations might be misdirected if guided by auscultation alone5. Even wave capnography can be affected by factors such as low cardiac output, low pulmonary flow, and use of epinephrine during CPR2. Therefore, more effective, accurate evaluation of the C-A-B status is mandatory.
When trying to search for the etiology of cardiac arrest or any potentially reversible factors during CPR, medical history and physical examination are often insufficient. The detection of reversible causes, such as the 5Hs (i.e., hypoxia, hypovolemia, hyperkalemia/hypokalemia, acidosis, and hypothermia) and the 5Ts (i.e., cardiac tamponade, tension pneumothorax, pulmonary thromboembolism, coronary thrombosis, and toxins or tablets), often requires advanced examinations.
Ultrasound (US) is a useful imaging modality in emergency and critical care settings. The European Resuscitation Council (ERC) Guidelines suggest that US can be an integral part of resuscitation6. US can readily identify critical but potentially reversible factors that negatively affect CPR, such as cardiac tamponade, pulmonary thromboembolism, and hypovolemia7,8,9. US also helps rule out pneumothorax and acute coronary syndrome. Moreover, US confers prognostic implications even when CPR is being performed. The presence of sonographic cardiac activity during CPR has been reported to confer higher chances of ROSC, survival, and hospital discharge10,11. In addition to sonographic evaluation of the heart and circulation status, tracheal US is employed for confirmation of proper endotracheal intubation12, while lung US is applied to confirm proper bilateral pulmonary ventilation13.
While high-quality CPR with minimal interruptions to the compressions is the most important factor for resuscitation, it is important to understand how to seamlessly integrate US into the process of resuscitation without interfering with CPR. We therefore developed a novel, ALS-compliant US-CAB protocol for use during CPR14. This paper presents a detailed description of the settings, personnel, and instruments necessary for better integration of the US protocol into the regular CPR process that first-line physicians can easily incorporate and implement into their practice.

<table border="0" cellpadding="0" cellspacing="0" style="border-collapse:
 collapse;width:516pt" width="688">
	<tbody>
		<tr height="21" style="height:15.75pt">
			<td class="xl65" height="21" style="height:15.75pt;width:162pt" width="216">Ultrasound</td>
			<td class="xl65" style="width:140pt" width="186">Cannon, Japan</td>
			<td class="xl65" style="width:89pt" width="119">SSA-550A</td>
			<td class="xl66" style="width:125pt" width="167">nil</td>
		</tr>
	</tbody>
</table>

ultrasonographic assessment during cardiopulmonary resuscitation

The US-CAB (Ultrasound, Circulation/Airway/Breathing) protocol integrates several sonographic techniques into a structured assessment of the circulation, airway, and breathing status of a patient during cardiopulmonary resuscitation (CPR) in an advanced life support-compliant manner. US-C provides a subxiphoid view of the heart, to look for potentially reversible causes of disease, such as pericardial effusion, pulmonary embolism, hypovolemia, and acute coronary thrombosis. Sonographic cardiac activity during CPR not only helps differentiate pseudo-pulseless electrical activity (PEA) from true PEA but also represents a higher chance of the return of spontaneous circulation (ROSC) and survival. Evaluation of the inferior vena cava (IVC) shows the fluid status of the patient and indicates the best methods to use for fluid resuscitation. If aortic dissection is suspected, a subxiphoid view of the aorta is suggested for identifying an intimal flap. Once intubation is done, tracheal ultrasound (US-A) at the suprasternal notch helps differentiate endotracheal intubation (one air-mucosal interface with one comet-tail) from esophageal intubation (double tract sign). Immediately following US-A, bilateral lung US (US-B) should be done to confirm proper bilateral ventilation using the lung sliding sign. In addition, US-C can be serially followed to see the dynamic changes in the cardiac chambers and IVC, or any cardiac contraction suggestive of ROSC. US-B can also detect coexisting lung or pleural pathologies without interfering with the performance of CPR. The main concern when implementing this method is maintaining high-quality CPR without delays in chest compressions when performing US-CAB. Rigorous training and continued practice are key to minimize any interruptions during resuscitation.

US-C with subxiphoid evaluation of the heart displays a cardiac four-chamber view as shown in Figure 3A. At this point, detection of any of the three typical patterns suggestive of specific etiologies or reversible factors is possible.
Identify the presence and characters of pericardial effusion: If pericardial effusion is present, notice if the right heart chambers (i.e., the right atrium or even the right ventricle) are compressed. If compression of the right at...

Watch this Scientific Journal Video about Ultrasonographic Assessment During Cardiopulmonary Resuscitation at JoVE.com

Ultrasonographic Assessment During Cardiopulmonary Resuscitation

Here, we present a US-CAB (Ultrasound, Circulation/Airway/Breathing) protocol for use during cardiopulmonary resuscitation (CPR). US-C evaluates the subxiphoid view of the heart and inferior vena cava. After intubation, tracheal US (US-A) and lung US (US-B) help confirm endotracheal intubation and proper ventilation.

The US-CAB (Ultrasound, Circulation/Airway/Breathing) protocol integrates several sonographic techniques into a structured assessment of the circulation, ...

The US-CAB protocol is a simple, structured protocol, that is used during resuscitation. It was named after the CAB sequences in the advanced life support guidelines. The US-CAB protocol can be used at during resuscitation.It has positive impact on patient outcomes. Ideally, a resuscitation team should be comprised of a leader, a member for airway management and ventilation, a member for chest compressions, a member for defibrillation, a member for intravenous catheterization and medication, and a recorder. A sonographer should also be present as an independent member of the team who is well-trained and experienced in resuscitation ultrasound and who can intervene and interpret the ultrasound images in a timely manner without interrupting or delaying the resuscitation efforts.When ultrasound is to be integrated into the CPR process, place a portable ultrasound machine in the caudal region of the patient, and set an alarm for every two minutes for CPR and every 10 seconds for pulse checks. To restrict the hands-off interval for pulse checks rhythm analysis, and simultaneous ultrasound evaluation to no longer than 10 seconds. At the start of CPR and at the end of the first five cycles of chest compressions use the subxiphoid four chamber view to check for pericardial effusion, the size of the left and right ventricles, and sonographic cardiac activity.Then turn the probe 90 degrees, parallel to the long axis of the patient to measure the diameter of the inferior vena cava. To check the endotracheal tube location after intubation, place the probe transversely at the suprasternal notch and note the one air mucosal interface with one comet tail artifact for tracheal intubation. Move the probe to the lateral side of the neck to reconfirm the single tract sign.And re-intubate, if there are two air mucosal interfaces with two comet tail artifacts. To check for proper ventilation, place the probe on both sides of the chest at the fourth to fifth intercostal spaces over the mid axillary line and look for lung sliding to evaluate pulmonary ventilation. If lung sliding is absent on one side, adjust the depth of the endotracheal tube until bilateral lung sliding is noticed.Then repeat the cardiac ultrasound every two minutes when chest compression is stopped for pulse checks. Continue to repeat the airway and breathing ultrasounds after patient transport and bed transfer. If compression of the right atrium and ventricle is noted during cardiac ultrasound with subxiphoid evaluation, pericardiocentesis is indicated and should be performed immediately.Pericardial effusion is also of diagnostic value. If the echogenicity is high or blood clots are present in the pericardial sac, the etiology could indicate serious complications. Cardiac ultrasound with subxiphoid evaluation of the inferior vena cava can be demonstrated by a vertical approach, and visual identification of the inferior vena cava diameter helps assess the fluid status of the patient.The inferior vena cava can also be evaluated in the subxiphoid transverse view. Cardiac ultrasound with subxiphoid verification of the descending abdominal aorta can be approached via a vertical or transverse view. This optional evaluation is recommended if aortic dissection is suspected from clinical presentation or when hemopericardium is observed by cardiac ultrasound cardiac evaluation.Endotracheal intubation is confirmed if a single tract sign is observed. If there is a double tract sign esophageal intubation is highly likely. Breathing ultrasound is usually performed immediately after airway ultrasound when auscultation or capnography is being performed but it can also be performed anytime during CPR when displacement of the endotracheal tube with one lung intubation is suspected or when specific etiologies such as pneumothorax or hemothorax need to be ruled out.Although the scanning sequence is organized, the order can be changed according to the experience of the sonographer. Focused training and continued practice are essential to minimize processes during chest compressions. Maintaining a good image of quality is an important issue for further studies.

ultrasonographic-assessment-during-cardiopulmonary-resuscitation

Research

JoVE Journal

Medicine

6.2K vistas.  National Taiwan University Hospital and College of Medicine. El protocolo US-CAB es un protocolo simple y estructurado, que se utiliza durante la reanimación. Fue nombrado en honor a las secuencias CAB en las pautas avanzadas de soporte vital. El protocolo US-CAB se puede utilizar durante la reanimación.Tiene un impacto positivo en los resultados de los pacientes. Idealmente, un equipo de reanimación debe estar compuesto por un líder, un miembro para el manejo de las vías respiratorias y ventilación, un miembro para las compresiones torác...