Rat Intubation and Sterile Environment Preparation
2:23
Left Pneumonectomy
4:34
Ribs and Intercostal Muscle Closure
5:37
Results: Representative Pulmonary Hypertension in Rats
6:40
Conclusion
Transcription
This protocol is significant because it produces the best possible model for pulmonary arterial hypertension. No other model produces the plexiform lesions found in human PAH patients. The main advantage is that we double the flow of blood in the
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The rodent left pneumonectomy is a valuable technique in pulmonary hypertension research. Here, we present a protocol to describe the rat pneumonectomy procedure and postoperative care to ensure minimal morbidity and mortality.