Skin Preparation and Ultraviolet (UV)-B Irradiation
1:39
Skin Isolation
2:29
Tissue Fixation
3:06
Frozen Tissue Block Preparation
4:15
Results: Representative Spatial and Temporal Control of Murine Melanoma Initiation
5:50
Conclusion
Transcription
Melanoma is widely diagnosed worldwide, with increasing incidence. These protocols allow the early stages of melanoma initiation to be carefully controlled, facilitating the study of its development. By controlling the time and location of melanoc
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The following procedure describes a method for spatial and temporal control of melanocytic tumor initiation in murine dorsal skin, using a genetically engineered mouse model. This protocol describes macroscopic as well as microscopic cutaneous melanoma initiation.