Our bladder model with a removed detrusor muscle is a new experimental approach to studying simultaneously the availability of urothelial mediators in the lamia propria and bladder lumen during bladder filling. This model can provide new insights
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The detrusor-free bladder model enables direct access to the suburothelium to study local mechanisms for regulation of biologically active mediator availability in suburothelium/lamina propria during storage and voiding of urine. The preparation closely resembles filling of an intact bladder and allows pressure-volume studies to be performed without systemic influences.