Antigenic Liposomes for Generation of Disease-specific Antibodies

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12.3K Views

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10:31 min

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October 25th, 2018

DOI :

10.3791/58285-v

October 25th, 2018

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Kyle J. Bednar*¹, Lakeya Hardy*²^,³, Johanna Smeekens*³^,⁴, Dharmendra Raghuwanshi⁵, Shiteng Duan⁶, Mike D. Kulis³^,⁴, Matthew S. Macauley⁵^,⁷

¹Janssen R&D, ²Department of Microbiology and Immunology, University of North Carolina, ³UNC Food Allergy Initiative, University of North Carolina, ⁴Department of Pediatrics, University of North Carolina, ⁵Department of Chemistry, University of Alberta, ⁶Department of Molecular Medicine, Scripps Research Institute, ⁷Department of Medical Microbiology and Immunology, University of Alberta

Podsumowanie

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Keywords Antigenic Liposomes

Disease specific Antibodies

Immunology

Allergy Mouse Model

Autoimmunity

Liposomal Nanoparticles

Heterobifunctional Crosslinker

SPDP

Dithiothreitol

DSPE PEG2000 Maleimide

Lipid linked Protein

Lyophilization

Rozdziały w tym wideo

0:04

Title

1:13

Protein Antigen-PEGylated Lipid Conjugation

2:57

Liposome Extrusion

4:24

Calcium Flux Monitoring of Antigenic Liposome-induced B Cell Activation

6:33

Mouse Peanut Sensitization and Ara h 2 (Ah2) Antigenic Liposome Challenge

8:26

Results: Representative Allergic Response Analyses

9:39

Conclusion

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