Measuring the In Vivo Burden of BCG lux in G. mellonella
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Results: BCG lux Dose Dependent Virulence
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Conclusion
Transcript
This protocol describes the use of Galleria mellonella as an alternative infection model to study tuberculosis, reducing the number of mammalian models used in research. When compared to conventional mammalian models such as mice, Galleria mellone
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Galleria mellonella was recently established as a reproducible, cheap, and ethically acceptable infection model for the Mycobacterium tuberculosis complex. Here we describe and demonstrate the steps taken to establish successful infection of G. mellonella with bioluminescent Mycobacterium bovis BCG lux.