JoVE Logo
Faculty Resource Center

Sign In

Toxicity Screens in Human Retinal Organoids for Pharmaceutical Discovery

DOI :

10.3791/62269-v

March 4th, 2021

March 4th, 2021

2,815 Views

1Lowy Medical Research Institute, 2The Scripps Research Institute

Here we present a step-by-step protocol to generate mature human retinal organoids and utilize them in a photoreceptor toxicity assay to identify pharmaceutical candidates for the age-related retinal degenerative disease macular telangiectasia type 2 (MacTel).

Tags

Toxicity Screens

-- Views

Related Videos

article

Fluorescent Nanoparticles for the Measurement of Ion Concentration in Biological Systems

article

GENPLAT: an Automated Platform for Biomass Enzyme Discovery and Cocktail Optimization

article

Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles

article

Polymer Microarrays for High Throughput Discovery of Biomaterials

article

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery

article

Eye Irritation Test (EIT) for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial (RhCE) Tissue Model

article

Isolation of Primary Murine Retinal Ganglion Cells (RGCs) by Flow Cytometry

article

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

article

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

article

Lucifer Yellow - A Robust Paracellular Permeability Marker in a Cell Model of the Human Blood-brain Barrier

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved