Infection of C. elegans with N. Parisiito Yield Immune-Primed Offspring
3:30
Testing Inherited Immunity to N. Parisii in C. elegans and Analysis of DY96-Stained Worms to Assess Infection Status
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Results: Study of Inherited Immunity in Genetically Tractable Worm Model
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Conclusion
副本
These protocols enable the study of inherited immunity to microsporidia. Techniques explained here can help us understand how immunity is transmitted across generations and the molecules determining immunity to microsporidia in offspring. C.elegan
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The infection of Caenorhabditis elegans by the microsporidian parasite Nematocida parisii enables the worms to produce offspring that are highly resistant to the same pathogen. This is an example of inherited immunity, a poorly understood epigenetic phenomenon. The present protocol describes the study of inherited immunity in a genetically tractable worm model.