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JoVE Journal

Cancer Research

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Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

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Models are needed to consistently needed to mimic cancer metastasis through the interaction with lymph nodes. In patients with both colorectal cancer and urothelial cell cancer of the bladder. Our orthotopic xenographic models described in this pa

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This protocol describes the generation of patient-derived orthotopic xenograft models by intra-vesically instilling high-grade urothelial cell carcinoma cells or intra-rectally injecting colorectal cancer cells into non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice for primary tumor growth and spontaneous metastases under the influence of lymph node stromal cells, which mimics the progression of human metastatic diseases.

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