Results: Representative EHBD Characterization and Analysis
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Conclusion
Transcription
This murine extrahepatic bile duct organoid system can address the limited access to preclinical cholangiopathies models and the limitations of pluripotent stem cell and liver-derived cholangiocyte organoid models. Our model is adult-tissue specif
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This protocol describes the production of a mouse extrahepatic bile duct 3-dimensional organoid system. These biliary organoids can be maintained in culture to study cholangiocyte biology. Biliary organoids express markers of both progenitor and biliary cells and are composed of polarized epithelial cells.