Outcross of LMO1 and MYCN Transgenic Lines to Create Metastatic Model
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Visualizing Tumor Burden in Transgenic Zebrafish Lines
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Results: Transgenic Zebrafish Model Overexpressing MYCN and LMO1 for Neuroblastoma Metastasis
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Conclusion
Trascrizione
These methods were used to develop the first zebrafish model of neuroblastoma metastasis. And to demonstrate that this model can faithfully recapitulate many features of metastasis seen in patients with high risk of neuroblastoma. The main advanta
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This paper introduces the method of developing, characterizing, and tracking in real-time the tumor metastasis in zebrafish model of neuroblastoma, specifically in the transgenic zebrafish line with overexpression of MYCN and LMO1, which develops metastasis spontaneously.