Results: Representative Cancer Cell Invasion Monitoring
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Conclusion
필기록
These methods can provide mechanistic insights into immune cell-mediated tumor cell cytotoxicity and invasive behavior in a 3D setting. The main advantage of this technique is that this 3D spheroid co-culture model does not require the transfer of
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The presented approach simultaneously evaluates cancer cell invasion in 3D spheroid assays and T-cell cytotoxicity. Spheroids are generated in a scaffold-free agarose multi-microwell cast. Co-culture and embedding in type I collagen matrix are performed within the same device which allows to monitor cancer cell invasion and T-cell mediated cytotoxicity.