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Bioengineering Human Microvascular Networks in Immunodeficient Mice

DOI :

10.3791/3065-v

6:55 min

July 11th, 2011

July 11th, 2011

11,960 Views

1Department of Cardiac Surgery, Children's Hospital Boston, Harvard Medical School

Here, we describe a methodology to deliver human cord blood-derived endothelial colony-forming cells (ECFCs) and bone marrow-derived mesenchymal stem cells (MSCs), embedded in a collagen/fibronectin gel, subcutaneously into immunodeficient mice. This cell/gel combination generates a human vascular network that connects with the mouse vasculature.

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Bioengineering

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