Human CD34+ Hematopoietic Stem Cells (HSC) Engraftment of Newborn Mice
4:18
Human Peripheral Blood Mononuclear Cell (PBMC) Engraftment of Juvenile Mice
7:29
Results: Representative Changes of Viral Load and CD4:CD8 Ratio in huNS -chainnull Mice after HIV Infection and after Anti-retroviral Therapy Introduction
8:41
Conclusion
Transcript
This procedure describes three models of humanized immunodeficient mice for the study of the dynamics of HIV infection. NSG humanized mice recapitulates on features of human immunity. In this case, permitting the study of chronic, acute, and react
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Described here are three experimental approaches for studying the dynamics of HIV infection in humanized mice. The first permits the study of chronic infection events, whereas the two latter allows for the study of acute events after primary infection or viral reactivation.