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Mouse Kidney Transplantation: Models of Allograft Rejection

DOI :

10.3791/52163-v

October 11th, 2014

October 11th, 2014

19,638 Views

1MRC Centre for Inflammation Research, The Queen's Medical Research Institute, The University of Edinburgh

Here, we present a protocol to study the immunology of rejection. The surgical model presented reports a short operating time and a concise technique. Depending on the donor-recipient strain combination, the transplanted kidney may develop acute cellular rejection or chronic allograft damage, defined by interstitial fibrosis and tubular atrophy.

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