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JoVE Journal

Bioengineering

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Mouse Model of Pressure Ulcers After Spinal Cord Injury

9.1K Views

06:51 min

March 9th, 2019

March 9th, 2019

9,136 Views

0:04

Title

0:35

T9-T10 Spinal Laminectomy

2:22

T9-T10 Complete Spinal Injury

3:11

Induction of Skin Pressure Ulcer after Complete SCI

4:22

Post-operative Animal Care, Euthanasia, and Tissue Collection for Histology

5:07

Results: Skin Wound Histology and Impact on Healing

6:15

Conclusion

Transkript

The overall goal of this study is to examine the effect of spinal cord injury on the dynamics of pressure ulcer development and healing in an animal model. The main advantage of this technique is that it does not impair animal movements, and is ve

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Here, we describe a simple method to induce clinically relevant skin pressure ulcers (PUs) in a mouse model of spinal cord injury (SCI). This model can be used in pre-clinical studies to screen for different therapeutics for healing PUs in SCI patients.

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