In the aim of reducing animal testing and because of the variability of the NH test, WHO encourages to develop in vitro approaches for evaluating rabies vaccine potency. This ELISA test shows a good concordance with a classical NH test in recogniz
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Here we describe an indirect ELISA sandwich immunocapture to determine the immunogenic glycoprotein contents in rabies vaccines. This test uses a neutralizing Monoclonal Antibody (mAb-D1) recognizing glycoprotein trimers. It is an alternative to the in vivo NIH test to follow the consistency of vaccine potency during production.