Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
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8.7K Views
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09:42 min
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June 26th, 2019
DOI :
June 26th, 2019
•George S. Karagiannis1,2,3, Jessica M. Pastoriza1,2,4, Lucia Borriello1,2, Rojin Jafari1,2, Anouchka Coste1,2,4, John S. Condeelis1,2,3,4, Maja H. Oktay1,2,3,5, David Entenberg1,2,3
1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 2Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, 3Integrated Imaging Program, Albert Einstein College of Medicine, 4Department of Surgery, Montefiore Medical Center, 5Department of Pathology, Montefiore Medical Center
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Title
0:55
Transplantation of Syngeneic Breast Tumors into Mouse Hosts with Fluorescent Macrophages
2:38
Preparation of Mouse for Imaging
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Evaluation of Extravascular Dextran Using Fixed Tissue Analysis
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Results: Visualization of Vasculature in Healthy and Diseased Tissues and TMEM-Mediated Vascular Permeability
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Conclusion
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