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Inducing Apical Periodontitis in Mice

DOI :

10.3791/59521-v

August 6th, 2019

August 6th, 2019

11,331 Views

1Institute of Dental Sciences, Faculty of Dental Medicine, Hebrew University of Jerusalem, 2Department of Endodontics, Hadassah Ein Kerem Medical Center

Here, we present a protocol to locally induce apical periodontitis in mice. We show how to drill a hole in the mouse's tooth and expose its pulp, in order to cause local inflammation. Analysis methods to investigate the nature of this inflammation, such as micro-CT and histology, are also demonstrated.

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Apical Periodontitis

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