Few large animal models exist to study abdominal aortic aneurysms, but these models are critical to assessing the viability of novel technologies and treatments for human disease. The combination of elastase and a compound called BAPN creates aneu
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This novel model creates robust infrarenal abdominal aortic aneurysms in swine using a combination of balloon angioplasty, elastase/collagenase perfusion, topical elastase application, and oral compound β-aminopropionitrile administration, which interferes with collagen cross-linking.